| Date | Game | |
| Thu Sep 3 | at Georgia Tech Atlanta, Ga. | |
| Sat Sep 12 | vs Louisville Clemson, S.C. | |
| Sat Sep 12, 7:30 ET | at Wake Forest Winston-Salem, N.C. | W 37-13 |
| Sat Sep 19 | vs Akron Clemson, S.C. | |
| Sat Sep 19, 4:00 ET | vs Citadel Clemson, S.C. | W 49-0 |
| Sat Sep 26 | vs Virginia Clemson, S.C. | |
| Fri Oct 2 | at Boston College Chestnut Hill, Mass. | |
| Sat Oct 3, 8:00 ET | vs Virginia Clemson, S.C. | W 41-23 |
| Sat Oct 10 | at Florida State Tallahassee, Fla. | |
| Sat Oct 10, 7:30 ET | vs Miami Clemson, S.C. | W 42-17 |
| Sat Oct 17 | vs NC State Clemson, S.C. | |
| Sat Oct 17, 12:00 ET | at Georgia Tech Atlanta, Ga. | W 73-7 |
| Sat Oct 24 | vs Syracuse Clemson, S.C. | |
| Sat Oct 24, 12:00 ET | vs Syracuse Clemson, S.C. | W 47-21 |
| Sat Oct 31, 12:00 ET | vs Boston College Clemson, S.C. | W 34-28 |
| Sat Nov 7 | at Notre Dame Notre Dame, Ind. | |
| Sat Nov 7, 7:30 ET | at Notre Dame Notre Dame, Ind. | L 40-47 |
| Sat Nov 14 | vs The Citadel Clemson, S.C. | |
| Sat Nov 21 | at Wake Forest Winston-Salem, N.C. | |
| Sat Nov 28 | vs South Carolina Clemson, S.C. | |
| Sat Nov 28, 3:30 ET | vs Pitt Clemson, S.C. | W 52-17 |
| Sat Dec 5, 7:30 ET | at Virginia Tech Blacksburg, Va. | W 45-10 |
| Sat Dec 19, 4:00 ET | at Notre Dame Charlotte, NC | W 34-10 |
| Fri Jan 1, 8:00 ET | vs Ohio State University New Orleans, LA | L 28-49 |