| Date | Game | |
| Mon Sep 4, 8:00 ET | at Duke Durham, N.C. | L 7-28 |
| Sat Sep 9, 2:15 ET | vs Charleston Southern Clemson, S.C. | W 66-17 |
| Sat Sep 16, 8:00 ET | vs Florida Atlantic Clemson, S.C. | W 48-14 |
| Sat Sep 23, 12:00 ET | vs Florida State Clemson, S.C. | L 24-31 |
| Sat Sep 30, 12:00 ET | at Syracuse Syracuse, N.Y. | W 31-14 |
| Sat Oct 7, 3:30 ET | vs Wake Forest Clemson, SC | W 17-12 |
| Sat Oct 21, 8:00 ET | at Miami Miami Gardens, Fla. | L 20-28 |
| Sat Oct 28, 2:00 ET | at NC State Raleigh, N.C. | L 17-24 |
| Sat Nov 4, 12:00 ET | vs Notre Dame Clemson, S.C. | W 31-23 |
| Sat Nov 11, 12:00 ET | vs Georgia Tech Clemson, S.C. | W 42-21 |
| Sat Nov 18, 3:30 ET | vs North Carolina Clemson, S.C. | W 31-20 |
| Sat Nov 25, 7:30 ET | at South Carolina Columbia, S.C. | W 16-7 |
| Fri Dec 29, 12:00 ET | vs Kentucky Jacksonville, Fla. | W 38-35 |