| Date | Game | |
| Mon Nov 4, 7:00 ET | vs Charleston Southern Clemson, SC | W 91-64 |
| Fri Nov 8, 7:00 ET | vs Saint Francis Clemson, SC | W 88-62 |
| Tue Nov 12, 7:00 ET | vs Eastern Kentucky Clemson, SC | W 75-62 |
| Sun Nov 17, 1:30 ET | at Boise State Boise, ID | L 71-84 |
| Thu Nov 21, 7:00 ET | vs Radford Clemson, SC | W 79-51 |
| Mon Nov 25, 6:30 ET | vs San Francisco Daytona Beach, Fla. | W 70-55 |
| Tue Nov 26, 4:00 ET | vs Penn State Daytona Beach, Fla. | W 75-67 |
| Fri Nov 29, 7:00 ET | vs Florida A&M Clemson, SC | W 86-58 |
| Tue Dec 3, 9:30 ET | vs Kentucky Clemson, SC | W 70-66 |
| Sat Dec 7, 12:00 ET | at Miami Coral Gables, FL | W 65-55 |
| Sat Dec 14, 11:00 AM ET | vs Memphis Clemson, SC | L 82-87 |
| Tue Dec 17, 7:00 ET | at South Carolina Columbia, SC | L 88-91 |
| Sat Dec 21, 2:00 ET | vs Wake Forest Clemson, SC | W 73-62 |
| Wed Jan 1, 4:00 ET | vs Stanford Clemson, SC | W 85-71 |
| Sat Jan 4, 8:30 ET | vs California Clemson, SC | W 80-68 |
| Tue Jan 7, 7:00 ET | at Louisville Louisville, Ky. | L 64-74 |
| Sat Jan 11, 2:00 ET | vs Florida State Clemson, SC | W 77-57 |
| Tue Jan 14, 9:00 ET | at Georgia Tech Atlanta, GA | W 70-59 |
| Sat Jan 18, 12:00 ET | at Pitt Pittsburgh, PA | W 78-75 |
| Wed Jan 22, 7:00 ET | vs Syracuse Clemson, SC | ACCN |
| Wed Jan 22, 7:00 ET | vs Syracuse Clemson, SC | W 86-72 |
| Sat Jan 25, 5:00 ET | at Virginia Tech Blacksburg, VA | W 72-57 |
| Sat Feb 1, 1:30 ET | at NC State Raleigh, NC | W 68-58 |
| Tue Feb 4, 9:00 ET | vs Georgia Tech Clemson, SC | ACCN |
| Sat Feb 8, 6:00 ET | vs Duke Clemson, SC | ESPN |
| Mon Feb 10, 7:00 ET | vs North Carolina Clemson, S.C. | ESPN |
| Sat Feb 15, 12:00 ET | at Florida State Tallahassee, Fla. | The CW |
| Sat Feb 22, 4:00 ET | at SMU Dallas, Texas | ACCN |
| Wed Feb 26, 7:00 ET | vs Notre Dame Clemson, SC | ACCN |
| Sat Mar 1, 12:00 ET | at Virginia Charlottesville, VA | ESPN/2 |
| Wed Mar 5, 7:00 ET | at Boston College Chestnut Hill, Mass. | ESPN2/U |
| Sat Mar 8, 6:00 ET | vs Virginia Tech Clemson, SC | ESPNU |