| Date | Game | |
| Thu Aug 22, 7:00 ET | vs Penn State Clemson, SC | W 3-0 |
| Fri Aug 30, 7:00 ET | at South Carolina Columbia, SC | T 2-2 |
| Fri Sep 6, 7:00 ET | vs Stanford Clemson, SC | L 2-3 |
| Tue Sep 10, 7:00 ET | vs Loyola Maryland Clemson, SC | W 6-0 |
| Fri Sep 13, 7:00 ET | at Boston College Newton, MA | W 1-0 |
| Mon Sep 16, 7:00 ET | at Holy Cross | ESPN+ |
| Fri Sep 20, 7:30 ET | vs Wake Forest | ACCN |
| Tue Sep 24, 7:00 ET | vs Liberty | ACCNX |
| Fri Sep 27, 7:00 ET | at Notre Dame | ESPNU |
| Fri Oct 4, 7:00 ET | vs North Carolina Clemson, S.C. | |
| Fri Oct 11, 8:00 ET | at Louisville Louisville, Ky. | |
| Tue Oct 15, 7:00 ET | vs Queens Clemson, SC | |
| Tue Oct 22, 7:00 ET | vs USC Upstate Clemson, SC | |
| Fri Oct 25, 8:00 ET | vs Syracuse Clemson, SC | |
| Tue Oct 29, 7:00 ET | vs Wofford Clemson, SC | |
| Fri Nov 1, 6:00 ET | at Virginia Tech Blacksburg, VA | |