| Date | Game | |
| Mon Nov 4, 2:30 ET | vs Jackson State Clemson, SC | W 78-44 |
| Thu Nov 7, 7:00 ET | vs NC Central Clemson, SC | W 91-33 |
| Mon Nov 11, 11:00 AM ET | vs Presbyterian Clemson, SC | W 81-33 |
| Wed Nov 20, 5:00 ET | vs South Carolina Clemson, SC | L 45-77 |
| Mon Nov 25, 12:00 ET | vs UAB Destin, Fla. | W 90-52 |
| Tue Nov 26, 2:30 ET | vs Alabama Destin, Fla. | L 39-73 |
| Sun Dec 1, 2:00 ET | vs Kennesaw State Clemson, SC | W 67-48 |
| Thu Dec 5, 8:00 ET | vs Florida Clemson, SC | L 64-77 |
| Sun Dec 8, 2:00 ET | vs Radford Clemson, SC | W 74-48 |
| Sun Dec 15, 4:00 ET | at Wake Forest Winston-Salem, N.C. | W 65-59 |
| Thu Dec 19, 4:00 ET | vs Georgia San Diego, Calif. | L 68-75 |
| Fri Dec 20, 6:30 ET | vs Hawaii San Diego, Calif. | W 72-58 |
| Sun Dec 29, 6:00 ET | at NC State | ACCN |
| Thu Jan 2, 7:00 ET | vs California Clemson, SC | |
| Sun Jan 5, 2:00 ET | vs Stanford Clemson, SC | |
| Thu Jan 9, 7:00 ET | vs Virginia Clemson, SC | |
| Sun Jan 12, 12:00 ET | vs Notre Dame Clemson, SC | |
| Thu Jan 16, 6:00 ET | at Florida State Tallahassee, Fla. | ACCNX |
| Sun Jan 19 | at Georgia Tech Atlanta, GA | |
| Thu Jan 23, 2:00 ET | vs Miami Clemson, SC | |
| Sun Jan 26, 2:00 ET | vs Syracuse Clemson, SC | ACCNX |
| Sun Feb 2, 2:00 ET | at Boston College Chestnut Hill, Mass. | ACCNX |
| Thu Feb 6, 7:00 ET | at Duke Durham, N.C. | ACCNX |
| Sun Feb 9, 2:00 ET | vs North Carolina Clemson, SC | ACCNX |
| Thu Feb 13, 7:00 ET | vs Georgia Tech Clemson, SC | |
| Sun Feb 16, 5:00 ET | at SMU Dallas, Texas | ACCN |
| Sun Feb 23, 1:00 ET | at Pitt Pittsburgh, PA | |
| Thu Feb 27, 6:00 ET | at Louisville Louisville, Ky. | |
| Sun Mar 2, 2:00 ET | vs Virginia Tech Clemson, SC | |