| Date | Game | |
| Fri Feb 18, 2:00 ET | vs Charlotte Tampa, Fla. | W 8-7 |
| Sat Feb 19, 4:00 ET | at South Florida Tampa, Fla. | L 4-8 |
| Sun Feb 20, 9:00 AM ET | vs Connecticut Tampa, Fla. | L 2-9 |
| Mon Feb 21, 5:30 ET | vs Xavier | W 7-6 |
| Fri Feb 25, 3:00 ET | vs Dartmouth | W 19-5 |
| Sat Feb 26, 1:00 ET | vs Dartmouth | L 4-6 |
| Sun Feb 27, 12:00 ET | vs Dartmouth | W 16-3 |
| Tue Mar 1, 5:00 ET | vs Morhead State | W 7-5 |
| Fri Mar 4, 5:00 ET | vs Akron | W 9-1 |
| Sat Mar 5, 1:00 ET | vs Akron | W 20-6 |
| Sat Mar 5, 4:30 ET | vs Akron | W 22-9 |
| Tue Mar 8, 12:00 ET | vs TCU | W 9-8 |
| Fri Mar 11, 1:00 ET | vs Michigan | W 5-3 |
| Fri Mar 11, 4:30 ET | vs Michigan | L 7-16 |
| Sun Mar 13, 1:00 ET | vs Michigan | W 13-1 |
| Tue Mar 15, 3:00 ET | vs Northern Kentucky | W 12-8 |
| Wed Mar 16, 11:00 AM ET | vs Bellarmine | W 11-5 |
| Fri Mar 18, 4:00 ET | vs Notre Dame | W 16-11 |
| Sat Mar 19, 1:00 ET | vs Notre Dame | W 8-1 |
| Sun Mar 20, 1:00 ET | vs Notre Dame | W 7-5 |
| Tue Mar 22, 4:00 ET | vs Lipscomb | L 2-6 |
| Fri Mar 25, 4:00 ET | at Boston College Brighton, Mass. | W 6-1 |
| Sat Mar 26, 2:00 ET | at Boston College | W 10-6 |
| Sun Mar 27, 1:00 ET | at Boston College | W 15-1 |
| Sun Mar 27, 1:00 ET | at Boston College Brighton, Mass. | ACCNX |
| Tue Mar 29, 6:00 ET | at Western Kentucky Bowling Green, Ky. | W 16-6 |
| Sat Apr 2, 12:00 ET | at Pitt | L 7-8 |
| Sat Apr 2, 3:45 ET | at Pitt | W 14-6 |
| Sun Apr 3, 2:00 ET | at Pitt | L 3-6 |
| Fri Apr 8, 6:00 ET | vs North Carolina | L 9-13 |
| Sat Apr 9, 1:00 ET | vs North Carolina | W 9-8 |
| Sun Apr 10, 1:00 ET | vs North Carolina | W 6-5 |
| Tue Apr 12, 6:00 ET | vs Cincinnati | W 18-10 |
| Thu Apr 14, 7:00 ET | at Florida State | L 1-8 |
| Fri Apr 15, 7:00 ET | at Florida State | L 4-9 |
| Sat Apr 16, 1:00 ET | at Florida State | L 9-10 |
| Tue Apr 19, 5:00 ET | vs Kentucky | W 4-2 |
| Fri Apr 22, 8:00 ET | vs NC State | W 11-4 |
| Sat Apr 23, 2:00 ET | vs NC State | L 10-15 |
| Sun Apr 24, 1:00 ET | vs NC State | W 11-7 |
| Tue Apr 26, 6:00 ET | vs Western Kentucky | W 11-4 |
| Fri Apr 29, 6:00 ET | vs Clemson | W 7-2 |
| Sat Apr 30, 1:00 ET | vs Clemson | W 10-8 |
| Sun May 1, 1:00 ET | vs Clemson | W 18-15 |
| Tue May 3, 6:00 ET | at Vanderbilt Nashville, Tenn. | W 1-0 |
| Sat May 7, 11:30 AM ET | at Wake Forest | L 3-14 |
| Sat May 7, 4:00 ET | at Wake Forest | W 6-2 |
| Sun May 8, 12:30 ET | at Wake Forest | T 5-5 |
| Tue May 10, 6:00 ET | vs Indiana | W 7-2 |
| Fri May 13, 3:00 ET | at Virginia Tech | W 8-1 |
| Sat May 14, 1:00 ET | at Virginia Tech | L 3-4 |
| Sun May 15, 11:00 AM ET | at Virginia Tech | L 4-6 |
| Tue May 17, 6:00 ET | vs Eastern Kentucky | W 10-3 |
| Thu May 19, 4:00 ET | vs Virginia | W 4-1 |
| Fri May 20, 4:00 ET | vs Virginia | L 7-16 |
| Sat May 21, 12:00 ET | vs Virginia | W 11-3 |
| Wed May 25, 11:00 AM ET | vs Pitt Charlotte, N.C. / ACC Championship | L 5-6 |
| Thu May 26, 11:00 AM ET | vs Georgia Tech Charlotte, N.C. / ACC Championship | L 4-9 |
| Fri Jun 3, 2:00 ET | vs Southeast Missouri State Louisville, Ky. / NCAA Regional | W 7-2 |
| Sat Jun 4, 4:00 ET | vs Michigan Louisville, Ky. / NCAA Regional | L 3-7 |
| Sun Jun 5, 12:00 ET | vs Oregon Louisville, Ky. / NCAA Regional | W 8-5 |
| Sun Jun 5, 4:00 ET | vs Michigan Louisville, KY / NCAA Regional | W 20-1 |
| Mon Jun 6, 12:00 ET | vs Michigan Louisville, KY / NCAA Regional | W 11-9 |
| Fri Jun 10, 8:30 ET | at Texas A&M College Station, Texas / NCAA Super Regional | L 4-5 |
| Sat Jun 11, 3:00 ET | at Texas A&M College Station, Texas / NCAA Super Regional | L 3-4 |