| Date | Game | |
| Fri Feb 16, 10:00 AM ET | vs Indiana State Tampa, Fla. | L 7-8 |
| Fri Feb 16, 2:00 ET | vs Connecticut Tampa, Fla. | L 3-4 |
| Wed Feb 21, 3:00 ET | vs Xavier Louisville, Ky. | L 1-9 |
| Fri Feb 23, 2:00 ET | vs St. Bonaventure Louisville, Ky. | L 3-4 |
| Fri Feb 23, 5:00 ET | vs St. Bonaventure Louisville, KY | W 21-3 |
| Sat Feb 24, 1:00 ET | vs St. Bonaventure Louisville, Ky. | W 15-2 |
| Sun Feb 25, 1:00 ET | vs St. Bonaventure Louisville, Ky. | W 18-11 |
| Tue Feb 27, 3:00 ET | vs Eastern Kentucky Louisville, Ky. | W 12-3 |
| Fri Mar 1, 3:00 ET | vs Youngstown State Louisville, Ky. | W 19-1 |
| Sat Mar 2, 1:00 ET | vs Youngstown State Louisville, Ky. | W 9-5 |
| Sun Mar 3, 1:00 ET | vs Youngstown State Louisville, Ky. | W 10-2 |
| Wed Mar 6, 3:00 ET | vs Morehead State Louisville, KY | W 19-5 |
| Fri Mar 8, 1:00 ET | vs Northwestern Louisville, Ky. | W 11-5 |
| Sat Mar 9, 1:00 ET | vs Northwestern Louisville, Ky. | W 10-2 |
| Sun Mar 10, 12:00 ET | vs Northwestern Louisville, Ky. | L 3-6 |
| Tue Mar 12, 3:00 ET | vs Lipscomb Louisville, Ky. | W 12-7 |
| Wed Mar 13, 11:00 AM ET | vs Lipscomb Louisville, Ky. | W 8-7 |
| Fri Mar 15, 6:00 ET | vs Virginia Tech Louisville, Ky. | W 9-6 |
| Sat Mar 16, 1:00 ET | vs Virginia Tech Louisville, Ky. | L 6-12 |
| Sun Mar 17, 12:00 ET | vs Virginia Tech Louisville, Ky. | L 1-8 |
| Tue Mar 19, 5:00 ET | vs Bellarmine Louisville, Ky. | W 11-1 |
| Thu Mar 21, 7:00 ET | at Wake Forest Winston-Salem, N.C. | L 7-16 |
| Fri Mar 22, 12:00 ET | at Wake Forest Winston-Salem, N.C. | L 1-5 |
| Sat Mar 23, 1:00 ET | at Wake Forest Winston-Salem, N.C. | W 7-3 |
| Tue Mar 26, 5:00 ET | vs Cincinnati Louisville, Ky. | W 11-5 |
| Thu Mar 28, 6:00 ET | at Florida State Tallahassee, Fla. | L 3-8 |
| Fri Mar 29, 6:00 ET | at Florida State Tallahassee, Fla. | W 5-2 |
| Sat Mar 30, 2:00 ET | at Florida State Tallahassee, Fla. | L 4-9 |
| Fri Apr 5, 6:00 ET | vs NC State Louisville, Ky. | W 11-1 |
| Sat Apr 6, 1:00 ET | vs NC State Louisville, Ky. | W 7-6 |
| Sun Apr 7, 1:00 ET | vs NC State Louisville, Ky. | W 7-6 |
| Tue Apr 9, 4:00 ET | at Western Kentucky Bowling Green, Ky. | L 2-3 |
| Fri Apr 12, 6:00 ET | vs Virginia Louisville, Ky. | L 3-21 |
| Sat Apr 13, 1:00 ET | vs Virginia Louisville, Ky. | W 14-10 |
| Sun Apr 14, 1:00 ET | vs Virginia Louisville, Ky. | L 7-16 |
| Tue Apr 16, 7:00 ET | vs Kentucky Louisville, Ky. | L 13-17 |
| Fri Apr 19, 7:00 ET | at Miami Coral Gables, Fla. | W 9-5 |
| Sat Apr 20, 8:00 ET | at Miami Coral Gables, Fla. | W 6-5 |
| Sun Apr 21, 2:00 ET | at Miami Coral Gables, Fla. | L 5-17 |
| Tue Apr 23, 5:00 ET | vs Western Kentucky Louisville, Ky. | W 16-5 |
| Fri Apr 26, 6:00 ET | vs Clemson Louisville, KY | L 11-12 |
| Sat Apr 27, 1:00 ET | vs Clemson Louisville, KY | W 7-6 |
| Sun Apr 28, 4:00 ET | vs Clemson Louisville, KY | L 7-17 |
| Tue Apr 30, 6:00 ET | vs Northern Kentucky Louisville, Ky. | W 11-7 |
| Thu May 2, 7:00 ET | at Boston College Brighton, MA | ACCN |
| Thu May 2, 7:00 ET | at Boston College Brighton, MA | W 12-7 |
| Fri May 3, 4:00 ET | at Boston College Brighton, MA | W 3-0 |
| Fri May 3, 5:00 ET | at Boston College Brighton, MA | ACCNX |
| Sat May 4, 12:00 ET | at Boston College Brighton, MA | ACCNX |
| Sat May 4, 12:00 ET | at Boston College Brighton, MA | W 5-3 |
| Tue May 7, 7:00 ET | at Vanderbilt Nashville, Tenn. | L 2-4 |
| Fri May 10, 6:00 ET | at North Carolina Chapel Hill, N.C. | L 4-14 |
| Sat May 11, 12:00 ET | at North Carolina Chapel Hill, N.C. | L 4-6 |
| Sun May 12, 12:00 ET | at North Carolina Chapel Hill, N.C. | L 7-16 |
| Thu May 16, 2:00 ET | vs Notre Dame Louisville, Ky. | W 5-3 |
| Thu May 16, 6:00 ET | vs Notre Dame Louisville, Ky. | W 5-1 |
| Fri May 17, 4:00 ET | vs Notre Dame Louisville, Ky. | W 14-6 |
| Tue May 21, 11:00 AM ET | vs Miami Charlotte, N.C. | L 5-8 |
| Fri May 24, 3:00 ET | vs Clemson Charlotte, N.C. | L 7-8 |