| Date | Game | |
| Wed Sep 2 | vs NC State Louisville, Ky. | |
| Sat Sep 12 | at Clemson Clemson, S.C. | |
| Sat Sep 12, 8:00 ET | vs Western Kentucky Louisville, Ky. | W 35-21 |
| Sat Sep 19 | vs Murray State Louisville, Ky. | |
| Sat Sep 19, 7:30 ET | vs Miami Louisville, Ky. | L 34-47 |
| Sat Sep 26 | vs Western Kentucky Louisville, Ky. | |
| Sat Sep 26, 12:00 ET | at Pitt Pittsburgh, Pa. | L 20-23 |
| Sat Oct 3 | at Syracuse Syracuse, N.Y. | |
| Fri Oct 9, 7:00 ET | at Georgia Tech Atlanta, Ga. | L 27-46 |
| Sat Oct 10 | at Boston College Chestnut Hill, Mass. | |
| Sat Oct 17, 2:30 ET | at Notre Dame Notre Dame, Ind. | L 7-12 |
| Sat Oct 24 | vs Florida State Louisville, Ky. | W 48-16 |
| Sat Oct 24 | vs Florida State Louisville, Ky. | |
| Sat Oct 31 | vs Virginia Tech Louisville, Ky. | |
| Sat Oct 31 | vs Virginia Tech Louisville, Ky. | L 35-42 |
| Sat Nov 7 | at Virginia Charlottesville, Va. | |
| Sat Nov 14 | vs Wake Forest Louisville, Ky. | |
| Sat Nov 14, 3:31 ET | at Virginia Charlottesville, Va. | L 17-31 |
| Fri Nov 20, 7:00 ET | vs Syracuse Louisville, Ky. | W 30-0 |
| Sat Nov 21 | at Notre Dame Notre Dame, Ind. | |
| Sat Nov 28 | vs Kentucky Louisville, Ky. | |
| Sat Nov 28, 4:00 ET | at Boston College Chestnut Hill, Mass. | L 27-34 |
| Sat Dec 12, 12:00 ET | vs Wake Forest Louisville, Ky. | W 45-21 |