| Date | Game | |
| Sat Aug 31, 12:00 ET | vs Austin Peay Louisville, Ky. | W 62-0 |
| Sat Sep 7, 3:30 ET | vs Jacksonville State Louisville, Ky. | W 49-14 |
| Sat Sep 21, 3:30 ET | vs Georgia Tech Louisville, Ky. | W 31-19 |
| Sat Sep 28, 3:30 ET | at Notre Dame South Bend, Ind. | L 24-31 |
| Sat Oct 5, 12:00 ET | vs SMU Louisville, Ky. | L 27-34 |
| Sat Oct 12, 3:30 ET | at Virginia Charlottesville, Va. | W 24-20 |
| Sat Oct 19, 12:00 ET | vs Miami Louisville, Ky. | L 45-52 |
| Fri Oct 25, 7:30 ET | at Boston College Chestnut Hill, Mass. | W 31-27 |
| Sat Nov 2, 7:30 ET | at Clemson | ESPN |
| Sat Nov 16 | at Stanford Stanford, Calif. | |
| Sat Nov 23 | vs Pittsburgh Louisville, Ky. | |
| Sat Nov 30 | at Kentucky Lexington, Ky. | |