| Date | Game | |
| Mon Nov 4, 7:00 ET | vs Morehead State Louisville, Ky. | W 93-45 |
| Sat Nov 9, 12:00 ET | vs Tennessee Louisville, Ky. | L 55-77 |
| Tue Nov 19, 7:00 ET | vs Bellarmine Louisville, Ky. | W 100-68 |
| Fri Nov 22, 7:00 ET | vs Winthrop Louisville, Ky. | W 76-61 |
| Wed Nov 27, 12:00 ET | vs Indiana Paradise, Bahamas | W 89-61 |
| Thu Nov 28 | vs West Virginia Paradise, Bahamas | W 79-70 |
| Fri Nov 29, 5:30 ET | vs Oklahoma Paradise, Bahamas | L 64-69 |
| Tue Dec 3, 9:00 ET | vs Ole Miss Louisville, Ky. | L 63-86 |
| Sun Dec 8, 6:00 ET | vs Duke Louisville, Ky. | L 65-76 |
| Wed Dec 11, 7:00 ET | vs UTEP Louisville, Ky. | W 77-74 |
| Sat Dec 14, 5:15 ET | at Kentucky Lexington, Ky. | L 85-93 |
| Sat Dec 21, 2:00 ET | at Florida State Tallahassee, Fla. | W 90-76 |
| Sat Dec 28, 12:00 ET | vs Eastern Kentucky Louisville, Ky. | W 78-76 |
| Wed Jan 1, 6:00 ET | vs North Carolina Louisville, Ky. | W 83-70 |
| Sat Jan 4, 4:00 ET | at Virginia Charlottesville, Va. | W 70-50 |
| Tue Jan 7, 7:00 ET | vs Clemson Louisville, Ky. | W 74-64 |
| Sat Jan 11, 12:00 ET | at Pittsburgh Pittsburgh, Pa. | W 82-78 |
| Tue Jan 14, 7:00 ET | at Syracuse Syracuse, N.Y. | ACCN |
| Tue Jan 14, 7:00 ET | at Syracuse Syracuse, N.Y. | W 85-61 |
| Sat Jan 18, 12:00 ET | vs Virginia Louisville, Ky. | W 81-67 |
| Tue Jan 21, 9:00 ET | at SMU Dallas, Texas | W 98-73 |
| Tue Jan 28, 7:00 ET | vs Wake Forest Louisville, Ky. | W 72-59 |
| Sat Feb 1, 3:45 ET | at Georgia Tech Atlanta, Ga. | L 70-77 |
| Wed Feb 5, 7:00 ET | at Boston College Chestnut Hill, Mass. | W 84-58 |
| Sat Feb 8, 2:00 ET | vs Miami Louisville, Ky. | W 88-78 |
| Wed Feb 12, 7:00 ET | at NC State Raleigh, N.C. | W 91-66 |
| Sun Feb 16, 8:00 ET | at Notre Dame South Bend, Ind. | W 75-60 |
| Sat Feb 22, 12:00 ET | vs Florida State Louisville, Ky. | W 89-81 |
| Tue Feb 25, 9:00 ET | at Virginia Tech Blacksburg, Va. | W 71-66 |
| Sat Mar 1, 6:00 ET | vs Pittsburgh Louisville, Ky. | W 79-68 |
| Wed Mar 5, 9:00 ET | vs Cal Louisville, Ky. | W 85-68 |
| Sat Mar 8, 2:00 ET | vs Stanford Louisville, Ky. | W 68-48 |
| Thu Mar 13, 7:00 ET | vs Stanford Charlotte, NC | W 75-73 |
| Fri Mar 14, 9:30 ET | vs Clemson Charlotte, NC | W 76-73 |
| Sat Mar 15, 8:30 ET | vs Duke Charlotte, NC | L 62-73 |
| Thu Mar 20, 12:15 ET | vs Creighton Lexington, KY | L 75-89 |