| Date | Game | |
| Mon Nov 4, 7:00 ET | vs Morehead State Louisville, Ky. | W 93-45 |
| Sat Nov 9, 12:00 ET | vs Tennessee Louisville, Ky. | L 55-77 |
| Tue Nov 19, 7:00 ET | vs Bellarmine Louisville, Ky. | W 100-68 |
| Fri Nov 22, 7:00 ET | vs Winthrop Louisville, Ky. | W 76-61 |
| Wed Nov 27, 12:00 ET | vs Indiana Paradise, Bahamas | W 89-61 |
| Thu Nov 28 | vs West Virginia Paradise, Bahamas | W 79-70 |
| Fri Nov 29, 5:30 ET | vs Oklahoma Paradise, Bahamas | L 64-69 |
| Tue Dec 3, 9:00 ET | vs Ole Miss | ACCN |
| Sun Dec 8, 6:00 ET | vs Duke | ACCN |
| Wed Dec 11, 7:00 ET | vs UTEP | ACCNX |
| Sat Dec 14, 5:15 ET | at Kentucky | ESPN |
| Sat Dec 21, 2:00 ET | at Florida State Tallahassee, Fla. | The CW |
| Sat Dec 28, 12:00 ET | vs Eastern Kentucky Louisville, Ky. | The CW |
| Wed Jan 1 | vs North Carolina Louisville, Ky. | ACCN |
| Sat Jan 4, 4:00 ET | at Virginia Charlottesville, Va. | ACCN |
| Tue Jan 7, 7:00 ET | vs Clemson Louisville, Ky. | ESPN2/U |
| Sat Jan 11, 12:00 ET | at Pittsburgh Pittsburgh, Pa. | ESPN2 |
| Tue Jan 14, 7:00 ET | at Syracuse Syracuse, N.Y. | ACCN |
| Tue Jan 14, 7:00 ET | at Syracuse Syracuse, N.Y. | ACCN |
| Sat Jan 18, 12:00 ET | vs Virginia Louisville, Ky. | ESPN2/U |
| Tue Jan 21, 9:00 ET | at SMU Dallas, Texas | ACCN |
| Tue Jan 28, 7:00 ET | vs Wake Forest Louisville, Ky. | ACCN |
| Sat Feb 1, 3:45 ET | at Georgia Tech Atlanta, Ga. | The CW |
| Wed Feb 5, 7:00 ET | at Boston College Chestnut Hill, Mass. | ACCN |
| Sat Feb 8, 2:00 ET | vs Miami Louisville, Ky. | ESPN2 |
| Wed Feb 12, 7:00 ET | at NC State Raleigh, N.C. | ESPN2/U |
| Sun Feb 16, 8:00 ET | at Notre Dame South Bend, Ind. | ACCN |
| Sat Feb 22, 12:00 ET | vs Florida State Louisville, Ky. | The CW |
| Tue Feb 25, 9:00 ET | at Virginia Tech Blacksburg, Va. | ACCN |
| Sat Mar 1, 6:00 ET | vs Pittsburgh Louisville, Ky. | ESPN2 |
| Wed Mar 5, 9:00 ET | vs Cal Louisville, Ky. | ACCN |
| Sat Mar 8, 2:00 ET | vs Stanford Louisville, Ky. | ESPNU |