| Date | Game | |
| Thu Aug 26, 8:00 ET | at Saint Louis St. Louis, MO | L 1-2 |
| Mon Aug 30, 7:30 ET | vs Evansville Louisville, KY | W 2-1 |
| Fri Sep 3, 7:30 ET | vs Bellarmine Louisville, KY | W 1-0 |
| Tue Sep 7, 7:30 ET | vs Kentucky Louisville, KY | L 1-3 |
| Fri Sep 10, 8:00 ET | vs Wake Forest Louisville, KY | W 3-0 |
| Fri Sep 17, 7:00 ET | at Syracuse Syracuse, NY | W 5-4 |
| Tue Sep 21, 7:30 ET | vs Northern Kentucky Louisville, KY | W 4-0 |
| Fri Sep 24, 7:30 ET | vs Boston College Louisville, KY | W 2-0 |
| Tue Sep 28, 7:30 ET | vs Western Illinois Louisville, KY | W 7-1 |
| Fri Oct 1, 7:00 ET | at Duke Durham, NC | L 1-3 |
| Fri Oct 8, 5:00 ET | at Virginia Tech Blacksburg, VA | L 2-4 |
| Tue Oct 12, 7:00 ET | vs Eastern Illinois Louisville, KY | W 5-0 |
| Fri Oct 15, 7:00 ET | vs North Carolina Louisville, KY | W 2-0 |
| Tue Oct 19, 7:00 ET | vs Oakland Louisville, KY | L 1-2 |
| Fri Oct 22, 7:00 ET | vs NC State Louisville, KY | W 2-1 |
| Fri Oct 29, 7:00 ET | at Clemson Clemson, SC | L 1-5 |
| Sun Nov 7, 6:00 ET | vs Notre Dame Louisville, KY | T 1-1 |
| Thu Nov 18, 6:30 ET | vs Bowling Green Louisville, KY | L 0-1 |