| Date | Game | |
| Fri Feb 7, 4:00 ET | vs Middle Tennessee Leesburg, FL | W 11-3 |
| Fri Feb 7, 6:30 ET | vs Liberty Leesburg, FL | L 4-9 |
| Sat Feb 8, 1:00 ET | vs Rutgers Leesburg, FL | W 8-2 |
| Sat Feb 8, 3:30 ET | vs Radford Leesburg, FL | L 1-3 |
| Sun Feb 9, 11:00 AM ET | vs Cleveland State Leesburg, FL | W 22-2 |
| Fri Feb 14, 9:00 AM ET | vs Villanova Boca Raton, FL | W 5-1 |
| Fri Feb 14, 11:15 AM ET | vs Minnesota Boca Raton, FL | W 5-1 |
| Sat Feb 15, 9:00 AM ET | vs Minnesota Boca Raton, FL | W 2-1 |
| Sun Feb 16, 1:15 ET | vs Purdue Boca Raton, FL | L 3-9 |
| Sun Feb 16, 4:00 ET | at Florida Atlantic Boca Raton, FL | W 4-0 |
| Fri Feb 21, 9:00 AM ET | vs Kent State Tampa, FL | W 13-3 |
| Fri Feb 21, 1:30 ET | vs Wisconsin Tampa, FL | L 1-4 |
| Sat Feb 22, 9:00 AM ET | vs Michigan Tampa, FL | W 5-3 |
| Sat Feb 22, 1:35 ET | at USF Tampa, FL | L 1-6 |
| Sun Feb 23, 9:00 AM ET | vs Wisconsin Tampa, FL | W 5-1 |
| Wed Feb 26, 5:00 ET | vs Bellarmine LOUISVILLE, KY | W 10-0 |
| Fri Feb 28, 12:30 ET | vs Central Michigan LOUISVILLE, KY | W 8-1 |
| Fri Feb 28, 5:30 ET | vs Longwood LOUISVILLE, KY | W 8-0 |
| Sat Mar 1, 12:30 ET | vs Central Michigan LOUISVILLE, KY | W 13-9 |
| Sun Mar 2, 1:30 ET | vs Northwestern LOUISVILLE, KY | L 1-5 |
| Fri Mar 7, 6:00 ET | vs Notre Dame LOUISVILLE, KY | W 9-2 |
| Sat Mar 8, 1:00 ET | vs Notre Dame LOUISVILLE, KY | L 2-3 |
| Sun Mar 9, 12:00 ET | vs Notre Dame LOUISVILLE, KY | W 4-3 |
| Wed Mar 12, 5:00 ET | vs Eastern Kentucky LOUISVILLE, KY | W 10-2 |
| Fri Mar 14, 4:00 ET | vs Virginia Tech LOUISVILLE, KY | L 0-10 |
| Fri Mar 14, 6:00 ET | vs Virginia Tech LOUISVILLE, KY | L 2-5 |
| Sun Mar 16, 12:00 ET | vs Virginia Tech LOUISVILLE, KY | L 5-12 |
| Tue Mar 18, 4:30 ET | at Northern Kentucky Highland Heights, KY | W 15-4 |
| Fri Mar 21, 5:00 ET | at North Carolina Chapel Hill, N.C. | W 7-4 |
| Sat Mar 22, 2:00 ET | at North Carolina Chapel Hill, N.C. | L 5-13 |
| Sun Mar 23, 12:00 ET | at North Carolina Chapel Hill, N.C. | L 3-14 |
| Tue Mar 25, 7:00 ET | at Western Kentucky Bowling Green, KY | W 3-2 |
| Fri Mar 28, 6:00 ET | vs Duke Louisville, Ky. | L 5-7 |
| Fri Mar 28, 6:00 ET | vs Duke Louisville, KY | |
| Sat Mar 29, 2:00 ET | vs Duke Louisville, KY | L 1-5 |
| Sun Mar 30, 12:00 ET | vs Duke LOUISVILLE, KY | L 8-15 |
| Wed Apr 2, 6:00 ET | vs Kentucky LOUISVILLE, KY | L 3-8 |
| Wed Apr 9, 6:00 ET | at Indiana Bloomington, IN | L 3-8 |
| Fri Apr 11, 2:00 ET | at Boston College Brighton, Mass. | L 1-3 |
| Fri Apr 11, 4:00 ET | at Boston College Brighton, Mass. | W 5-2 |
| Sat Apr 12, 2:00 ET | at Boston College Brighton, Mass. | W 14-13 |
| Thu Apr 17, 5:00 ET | at Virginia Charlottesville, VA | W 6-5 |
| Fri Apr 18, 5:00 ET | at Virginia Charlottesville, VA | L 2-8 |
| Sat Apr 19, 12:00 ET | at Virginia Charlottesville, VA | L 0-6 |
| Tue Apr 22, 6:00 ET | vs Western Kentucky LOUISVILLE, KY | L 0-2 |
| Fri Apr 25, 6:00 ET | vs Florida State Louisville, KY | |
| Fri Apr 25, 6:00 ET | vs Florida State | |
| Sat Apr 26, 1:00 ET | vs Florida State | |
| Sun Apr 27, 6:00 ET | vs Florida State | |
| Thu May 1, 6:00 ET | at Pittsburgh Pittsburgh, PA | |
| Fri May 2, 6:00 ET | at Pittsburgh Pittsburgh, PA | |
| Sat May 3, 12:00 ET | at Pittsburgh Pittsburgh, PA | |
| Wed May 7 | vs ACC Softball Championship Chestnut Hill, MA | |