| Date | Game | |
| Fri Nov 12, 4:30 ET | at Arizona | L 59-61 |
| Tue Nov 16, 7:00 ET | vs Bellarmine Louisville, Ky. | W 82-25 |
| Wed Nov 17, 7:00 ET | vs UT Martin Louisville, Ky. | W 62-30 |
| Sat Nov 20, 5:00 ET | at Washington Seattle, Wash. | W 61-53 |
| Tue Nov 23, 8:00 ET | at Cal Poly San Luis Obispo, Calif. | W 72-32 |
| Sun Nov 28, 2:00 ET | at Colorado State Fort Collins, Colo. | W 71-56 |
| Thu Dec 2, 7:00 ET | vs Michigan Louisville, Ky. | W 70-48 |
| Sun Dec 5, 12:00 ET | vs Belmont Louisville, Ky. | W 80-66 |
| Sun Dec 12, 1:00 ET | vs Kentucky Louisville, Ky. | W 64-58 |
| Thu Dec 16, 8:00 ET | vs Eastern Kentucky Louisville, Ky. | W 82-38 |
| Sun Dec 19, 3:30 ET | at UCONN Uncasville, Conn. | W 69-64 |
| Thu Dec 30, 7:00 ET | vs Boston College Louisville, Ky. | W 79-49 |
| Sun Jan 2, 12:00 ET | at Georgia Tech Atlanta, Ga. | W 50-48 |
| Thu Jan 6, 6:00 ET | vs Pitt Louisville, Ky. | W 81-39 |
| Thu Jan 13, 7:00 ET | vs Syracuse Louisville, Ky. | W 84-71 |
| Sun Jan 16, 12:00 ET | at Boston College Chestnut Hill, Mass. | W 63-53 |
| Thu Jan 20, 7:30 ET | at NC State Raleigh, N.C. | L 59-68 |
| Sun Jan 23, 2:00 ET | vs Wake Forest Louisville, Ky. | W 72-60 |
| Thu Jan 27, 8:00 ET | vs Florida State Louisville, Ky. | W 75-62 |
| Sun Jan 30, 3:00 ET | vs Duke Louisville, Ky. | W 77-65 |
| Tue Feb 1, 7:00 ET | at Miami Coral Gables, Fla. | W 69-66 |
| Thu Feb 3, 6:00 ET | at Clemson Clemson, S.C. | W 93-71 |
| Sun Feb 6, 12:00 ET | at Syracuse Syracuse, N.Y. | W 100-64 |
| Thu Feb 10, 7:00 ET | vs Virginia | ACCNX |
| Thu Feb 10, 7:00 ET | vs Virginia Tech | ACCNX |
| Sun Feb 13, 2:00 ET | vs Notre Dame Louisville, Ky. | W 73-47 |
| Thu Feb 17, 6:00 ET | at North Carolina Chapel Hill, N.C. | L 65-66 |
| Sun Feb 20, 2:00 ET | vs Virginia Tech Louisville, KY | W 70-56 |
| Thu Feb 24, 6:00 ET | at Pitt Pittsburgh, Pa. | W 66-55 |
| Sun Feb 27, 12:00 ET | at Notre Dame Notre Dame, Ind. | W 86-64 |
| Fri Mar 4, 6:00 ET | vs Miami | L 59-61 |
| Fri Mar 18, 6:00 ET | vs Albany Louisville, Ky. / NCAA Tournament | ESPN2 |
| Fri Mar 18, 6:00 ET | vs Albany Louisville, Ky. / NCAA Tournament | W 83-51 |
| Sun Mar 20, 7:00 ET | vs Gonzaga Louisville, Ky. / NCAA Tournament | W 68-59 |
| Sat Mar 26, 4:00 ET | vs Tennessee Wichita, Kan. / NCAA Sweet 16 | W 76-64 |
| Mon Mar 28, 9:00 ET | vs Michigan Wichita, Kan. / NCAA Elite 8 | W 62-50 |
| Fri Apr 1, 7:00 ET | vs South Carolina Minneapolis, Minn. / NCAA Final Four | L 59-72 |