| Date | Game | |
| Mon Nov 4, 2:30 ET | vs UCLA | |
| Fri Nov 8, 7:00 ET | vs Southern Indiana Louisville, Ky. | W 75-51 |
| Tue Nov 12, 7:00 ET | at UT Martin Martin, TN | W 86-64 |
| Sat Nov 16, 6:00 ET | at Kentucky Lexington, KY | L 61-71 |
| Thu Nov 21, 7:00 ET | vs Morehead State | |
| Sun Nov 24, 1:00 ET | vs South Florida | NBC Sports FAST Channel |
| Sat Nov 30, 3:00 ET | at Colorado | ESPN+ |
| Wed Dec 4, 5:00 ET | vs Oklahoma | ESPN2 |
| Sat Dec 7, 9:30 ET | vs UConn Brooklyn, NY (Barclays Center) | FOX |
| Thu Dec 12, 7:00 ET | vs Grambling State | ACCNX |
| Sun Dec 15, 1:00 ET | vs NC State Louisville, Ky. | ABC |
| Sat Dec 21, 5:00 ET | at Memphis Memphis, TN | |
| Sun Dec 29, 2:00 ET | at Boston College Chestnut Hill, Mass. | |
| Thu Jan 2, 7:00 ET | vs Miami Louisville, Ky. | |
| Sun Jan 5, 4:00 ET | at Wake Forest Winston-Salem, NC | |
| Thu Jan 9, 6:00 ET | at Pitt Pittsburgh, PA | |
| Sun Jan 12, 4:00 ET | vs Georgia Tech Louisville, Ky. | |
| Thu Jan 16, 7:00 ET | vs Syracuse Louisville, Ky. | |
| Sun Jan 19, 4:00 ET | at Virginia Tech Blacksburg, VA | |
| Sun Jan 26, 2:00 ET | at Virginia Charlottesville, VA | |
| Thu Jan 30, 8:00 ET | at SMU Dallas, Texas | |
| Sun Feb 2, 12:00 ET | vs Notre Dame Louisville, Ky. | |
| Thu Feb 6, 8:00 ET | vs Cal Louisville, Ky. | |
| Sun Feb 9, 12:00 ET | vs Stanford Louisville, Ky. | |
| Thu Feb 13, 6:00 ET | at Florida State Tallahassee, Fla. | |
| Thu Feb 20, 7:00 ET | at Duke Durham, N.C. | |
| Sun Feb 23, 2:00 ET | vs North Carolina Louisville, Ky. | |
| Thu Feb 27, 6:00 ET | vs Clemson Louisville, Ky. | |
| Sun Mar 2 | at Notre Dame South Bend, Ind. | |