| Date | Game | |
| Fri Feb 9, 5:00 ET | at Denver Denver, CO | L 8-16 |
| Sun Feb 11, 2:00 ET | at Colorado Boulder, CO | L 15-16 |
| Fri Feb 16, 12:00 ET | vs Marquette Louisville, KY | W 14-9 |
| Sun Feb 18, 1:00 ET | at Lindenwood St. Charles, MO | L 9-12 |
| Sat Feb 24, 6:00 ET | vs Virginia Tech Louisville, KY | L 10-14 |
| Sat Mar 2, 12:00 ET | at Pittsburgh Pittsburgh, PA | W 19-11 |
| Wed Mar 6, 12:00 ET | at Cincinnati Cincinnati OH | W 18-13 |
| Sun Mar 10, 12:00 ET | vs Boston College Louisville, KY | L 14-17 |
| Sat Mar 16, 2:00 ET | vs Clemson Louisville, KY | W 13-12 |
| Thu Mar 21, 12:00 ET | at Liberty Lynchburg, VA | W 11-8 |
| Sat Mar 23, 11:00 AM ET | at North Carolina Chapel Hill, NC | L 12-18 |
| Wed Mar 27, 7:00 ET | vs Xavier Louisville, KY | W 15-7 |
| Sat Mar 30, 12:00 ET | at Syracuse Syracuse, NY | L 12-22 |
| Sat Apr 6, 11:30 AM ET | vs Virginia Louisville, KY | L 8-13 |
| Tue Apr 9, 1:00 ET | vs Ohio State Louisville, KY | W 22-10 |
| Fri Apr 12, 3:00 ET | at Duke Durham, NC | L 11-14 |
| Thu Apr 18, 12:00 ET | vs Notre Dame Louisville, KY | L 10-23 |
| Sun Apr 21, 12:00 ET | at Virginia Tech Blacksburg, VA | W 13-11 |
| Wed Apr 24, 11:00 AM ET | vs Syracuse Charlotte, NC | L 8-17 |