| Date | Game | |
| Thu Aug 15, 7:30 ET | vs Bellarmine Louisville, Ky. | W 7-0 |
| Sun Aug 18, 7:30 ET | vs UAB Louisville, Ky. | W 3-1 |
| Thu Aug 22, 7:30 ET | vs New Hampshire Louisville, Ky. | T 1-1 |
| Sun Aug 25, 5:00 ET | at Northern Kentucky Highland Heights, KY | W 2-1 |
| Thu Aug 29, 7:00 ET | at Cincinnati Cincinnati, OH | T 1-1 |
| Sun Sep 1, 7:00 ET | vs Evansville Louisville, Ky. | W 3-0 |
| Thu Sep 5, 7:30 ET | vs UT Martin Louisville, Ky. | W 2-0 |
| Sun Sep 8, 7:00 ET | vs Dayton Louisville, Ky. | L 0-1 |
| Sat Sep 14, 7:00 ET | at Pitt Pittsburgh, Pa. | L 1-3 |
| Thu Sep 26, 7:00 ET | at Virginia Tech Blacksburg, VA | L 1-5 |
| Sun Sep 29, 1:00 ET | vs NC State Louisville, KY | W 1-0 |
| Thu Oct 3, 7:00 ET | at North Carolina Chapel Hill, NC | L 0-5 |
| Sun Oct 6, 1:00 ET | at Duke Durham, N.C. | L 1-3 |
| Sat Oct 12, 5:00 ET | vs Notre Dame Louisville, Ky. | T 0-0 |
| Thu Oct 17, 7:00 ET | vs Stanford Louisville, Ky. | L 0-1 |
| Sun Oct 20, 12:00 ET | vs Cal | |
| Thu Oct 24, 7:00 ET | vs Boston College Louisville, Ky. | |
| Thu Oct 31, 7:00 ET | at Clemson Clemson, SC | |