| Date | Game | |
| Tue Aug 27, 9:00 ET | vs Wisconsin Louisville, Ky. | W 3-1 |
| Sun Sep 1, 4:00 ET | vs Tennessee Louisville, Ky. | W 3-0 |
| Tue Sep 3, 7:30 ET | at Penn State University Park, PA | L 0-3 |
| Fri Sep 6, 3:00 ET | vs South Dakota Highland Heights, Ky. | W 3-1 |
| Sat Sep 7, 2:00 ET | vs Missouri Highland Heights, Ky. | W 3-0 |
| Sun Sep 8, 2:00 ET | at Northern Kentucky Highland Heights, KY | W 3-0 |
| Sat Sep 14, 1:30 ET | vs Northern Iowa Louisville, Ky. | W 3-0 |
| Wed Sep 18, 7:00 ET | at Kentucky | ESPN |
| Sun Sep 22, 12:30 ET | vs Nebraska Louisville, Ky. | ABC |
| Fri Sep 27, 7:00 ET | vs California | ACCNX |
| Sun Sep 29, 3:00 ET | vs Stanford | ESPN |
| Fri Oct 4, 6:00 ET | vs Clemson Louisville, Ky. | |
| Sun Oct 6, 1:30 ET | vs Georgia Tech | ACCN |
| Fri Oct 11, 6:30 ET | at Florida State Tallahassee, FL | |
| Sun Oct 13, 1:00 ET | at Miami Coral Gables, FL | ACCNX |
| Fri Oct 18, 7:00 ET | vs Wake Forest Louisville, Ky. | |
| Sun Oct 20, 1:00 ET | vs NC State Louisville, Ky. | |
| Fri Oct 25, 7:00 ET | at Pittsburgh Pittsburgh, PA | |
| Sun Oct 27, 2:00 ET | at Southern Methodist Dallas, TX | |
| Wed Oct 30, 7:00 ET | vs Notre Dame Louisville, Ky. | |
| Sat Nov 2, 3:00 ET | at Notre Dame South Bend, Ind. | |
| Fri Nov 8, 6:00 ET | at Syracuse Syracuse, NY | |
| Sun Nov 10, 1:00 ET | at Boston College Chestnut Hill, MA | |
| Fri Nov 15, 7:00 ET | vs Duke Louisville, Ky. | |
| Sun Nov 17, 1:00 ET | vs North Carolina Louisville, Ky. | |
| Fri Nov 22, 7:00 ET | at Virginia Charlottesville, VA | |
| Sun Nov 24, 1:00 ET | at Virginia Tech Blacksburg, VA | |
| Wed Nov 27, 7:00 ET | vs Pittsburgh Louisville, Ky. | |
| Sat Nov 30, 4:00 ET | at Stanford Stanford, CA | |