| Date | Game | |
| Fri Feb 26, 4:00 ET | at Wake Forest Winston-Salem, N.C. | L 8-10 |
| Sat Feb 27, 4:30 ET | at Wake Forest Winston-Salem, N.C. | W 5-4 |
| Sun Feb 28, 1:00 ET | at Wake Forest Winston-Salem, N.C. | W 10-0 |
| Fri Mar 5, 4:00 ET | at Clemson Clemson, S.C. | L 7-13 |
| Sat Mar 6, 3:00 ET | at Clemson Clemson, S.C. | W 3-1 |
| Sun Mar 7, 1:00 ET | at Clemson Clemson, S.C. | W 3-2 |
| Fri Mar 12, 3:00 ET | at Virginia Charlottesville, Va. | W 10-5 |
| Sat Mar 13, 1:00 ET | at Virginia Charlottesville, Va. | W 12-4 |
| Sun Mar 14, 1:00 ET | at Virginia Charlottesville, Va. | W 8-3 |
| Fri Mar 19, 4:00 ET | vs Duke South Bend, Ind. | W 6-4 |
| Sat Mar 20, 2:00 ET | vs Duke South Bend, Ind. | W 6-2 |
| Sun Mar 21, 1:00 ET | vs Duke South Bend, Ind. | L 0-2 |
| Tue Mar 23, 5:00 ET | vs Valparaiso South Bend, Ind. | W 6-3 |
| Fri Mar 26, 4:00 ET | vs Louisville Notre Dame, Ind. | L 4-7 |
| Sat Mar 27, 2:00 ET | vs Louisville Notre Dame, Ind. | W 5-3 |
| Sat Apr 3, 1:00 ET | at Pitt Pittsburgh, Pa. | W 4-1 |
| Sun Apr 4, 3:00 ET | at Pitt Pittsburgh, Pa. | L 2-3 |
| Mon Apr 5, 1:00 ET | at Pitt Pittsburgh, Pa. | W 11-5 |
| Fri Apr 9, 5:00 ET | vs Georgia Tech | W 10-9 |
| Sat Apr 10, 2:00 ET | vs Georgia Tech | W 7-0 |
| Sun Apr 11, 1:00 ET | vs Georgia Tech Notre Dame, Ind. | L 2-4 |
| Tue Apr 13, 5:00 ET | vs Central Michigan South Bend, Ind. | W 8-4 |
| Fri Apr 16, 5:00 ET | vs NC State South Bend, Ind. (Frank Eck Stadium) | W 3-2 |
| Sat Apr 17, 2:00 ET | vs NC State South Bend, Ind. (Frank Eck Stadium) | L 2-5 |
| Sun Apr 18, 1:00 ET | vs NC State South Bend, Ind. (Frank Eck Stadium) | W 11-2 |
| Tue Apr 20, 5:00 ET | vs Butler South Bend, Ind. | |
| Fri Apr 23, 5:30 ET | at Boston College Brighton, Mass. | L 0-10 |
| Sat Apr 24, 2:00 ET | at Boston College Brighton, Mass. | W 5-2 |
| Sat Apr 24, 6:00 ET | at Boston College Brighton, Mass. | W 13-9 |
| Tue Apr 27, 5:00 ET | vs Valparaiso South Bend, Ind. | W 8-7 |
| Fri Apr 30, 5:00 ET | vs North Carolina South Bend, Ind. | W 4-0 |
| Sat May 1, 2:00 ET | vs North Carolina South Bend, Ind. | W 13-12 |
| Sun May 2, 1:00 ET | vs North Carolina South Bend, Ind. | W 19-5 |
| Fri May 7, 6:00 ET | vs Florida State South Bend, Ind. | L 2-5 |
| Sat May 8, 1:00 ET | vs Florida State South Bend, Ind. | W 5-3 |
| Sun May 9, 1:00 ET | vs Florida State South Bend, Ind. | L 1-7 |
| Tue May 11, 4:00 ET | at Valparaiso Valparaiso, IN | W 7-4 |
| Thu May 20, 6:00 ET | at Virginia Tech Blacksburg, Va. | W 8-2 |
| Fri May 21, 6:00 ET | at Virginia Tech Blacksburg, Va. | W 4-0 |
| Sat May 22, 1:00 ET | at Virginia Tech Blacksburg, Va. | W 7-1 |
| Wed May 26, 3:00 ET | vs Virginia Tech Charlotte, NC | W 8-0 |
| Fri May 28, 11:00 AM ET | vs Virginia Charlotte, NC | L 1-14 |
| Fri Jun 4, 1:00 ET | vs Central Michigan South Bend, Ind. / NCAA Regional | W 10-0 |
| Sat Jun 5, 6:00 ET | vs UConn South Bend, Ind. / NCAA Regional | W 26-3 |
| Sun Jun 6, 6:00 ET | vs Central Michigan South Bend, Ind. / NCAA Regional | W 14-2 |
| Sat Jun 12, 2:00 ET | at Mississippi State Starkville, Miss. / NCAA Super Regional | L 8-9 |
| Sun Jun 13, 6:00 ET | at Mississippi State Starkville, Miss. / NCAA Super Regional | W 9-1 |
| Mon Jun 14, 7:00 ET | at Mississippi State Starkville, Miss. / NCAA Super Regional | L 7-11 |