| Date | Game | |
| Sat Nov 28, 8:00 ET | at Michigan State Breslin Center, East Lansing, MI | L 70-80 |
| Wed Dec 2, 7:00 ET | vs Western Michigan Purcell Pavilion Notre Dame, IN | RSN |
| Fri Dec 4, 8:00 ET | vs Tennessee Purcell Pavilion Notre Dame, IN | ACCN |
| Sat Dec 5, 11:00 AM ET | vs Purdue Fort Wayne Purcell Pavilion, Notre Dame, IN | ACCNX |
| Sun Dec 6, 7:00 ET | vs Detroit Mercy Purcell Pavilion, Notre Dame, IN | W 78-70 |
| Tue Dec 8, 7:30 ET | vs Ohio State Purcell Pavilion, Notre Dame, IN | L 85-90 |
| Sat Dec 12, 12:00 ET | at Kentucky Rupp Arena, Lexington, KY | W 64-63 |
| Wed Dec 16, 9:00 ET | vs Duke Joyce Center, Notre Dame, IN | L 65-75 |
| Sat Dec 19, 2:30 ET | vs Purdue Bankers Life Fieldhouse, Indianapolis, IN | L 78-88 |
| Wed Dec 23, 12:00 ET | vs Bellarmine Purcell Pavilion, Notre Dame, Ind. | W 81-70 |
| Wed Dec 30, 6:00 ET | vs Virginia Purcell Pavilion Notre Dame, IN | L 57-66 |
| Sat Jan 2, 2:00 ET | at Pitt Petersen Events Center, Pittsburgh, PA | ACCN |
| Sat Jan 2, 4:00 ET | at North Carolina Smith Center, Chapel Hill, NC | L 65-66 |
| Sun Jan 10, 6:00 ET | at Virginia Tech Cassell Coliseum, Blacksburg, VA | L 63-77 |
| Wed Jan 13, 4:30 ET | at Virginia John Paul Jones Arena, Charlottesville, VA | L 68-80 |
| Sat Jan 16, 4:00 ET | vs Boston College Purcell Pavilion Notre Dame, IN | W 80-70 |
| Sun Jan 24, 6:00 ET | at Miami Watsco Center, Coral Gables, FL | W 73-59 |
| Wed Jan 27, 7:00 ET | vs Virginia Tech Purcell Pavilion Notre Dame, IN | L 51-62 |
| Sat Jan 30, 8:00 ET | at North Carolina Smith Center, Chapel Hill, NC | ACCN |
| Sat Jan 30, 8:00 ET | at Pitt Petersen Events Center, Pittsburgh, PA | W 84-58 |
| Tue Feb 2, 5:00 ET | vs Wake Forest Purcell Pavilion Notre Dame, IN | W 79-58 |
| Sat Feb 6, 8:00 ET | at Georgia Tech McCamish Pavilion, Atlanta, GA | L 80-82 |
| Tue Feb 9, 4:30 ET | at Duke Cameron Indoor Stadium, Durham, NC | W 93-89 |
| Sun Feb 14, 6:00 ET | vs Miami Purcell Pavilion Notre Dame, IN | W 71-61 |
| Sat Feb 20, 2:00 ET | at Syracuse The Dome, Syracuse, NY | L 67-75 |
| Tue Feb 23, 7:00 ET | at Louisville KFC Yum Center, Louisville, KY | L 57-69 |
| Sat Feb 27, 2:00 ET | at Boston College Conte Forum, Chestnut Hill, MA | L 90-94 |
| Wed Mar 3, 7:00 ET | vs NC State Purcell Pavilion Notre Dame, IN | L 69-80 |
| Sat Mar 6, 12:00 ET | vs Florida State Purcell Pavilion, Notre Dame, IN | W 83-73 |
| Tue Mar 9, 7:00 ET | vs Wake Forest South Bend, Ind. | W 80-77 |
| Wed Mar 10, 9:00 ET | at North Carolina Greensboro, NC | L 59-101 |