| Date | Game | |
| Wed Nov 6, 7:30 ET | vs Stonehill South Bend, Ind. | W 89-60 |
| Mon Nov 11, 7:00 ET | vs Buffalo South Bend, Ind. | W 86-77 |
| Sat Nov 16, 1:00 ET | at Georgetown Washington, DC | W 84-63 |
| Tue Nov 19, 7:00 ET | vs North Dakota South Bend, Ind. | W 75-58 |
| Fri Nov 22, 7:00 ET | vs Elon | ACCNX |
| Tue Nov 26, 10:30 ET | vs Rutgers Las Vegas, NV | TBS |
| Thu Nov 28, 12:30 AM ET | vs Houston Las Vegas, NV | TBS |
| Sat Nov 30 | vs TBA Las Vegas, NV | truTV |
| Tue Dec 3, 7:00 ET | at Georgia | ESPNU |
| Sat Dec 7, 12:00 ET | vs Syracuse South Bend, Ind. | The CW |
| Sat Dec 7, 12:00 ET | vs Syracuse South Bend, Ind. | The CW |
| Wed Dec 11, 7:00 ET | vs Dartmouth | ESPN+ |
| Sun Dec 22, 6:00 ET | vs Le Moyne South Bend, Ind. | ACCN |
| Tue Dec 31, 2:30 ET | at Georgia Tech Atlanta, GA | ACCN |
| Sat Jan 4, 12:00 ET | vs North Carolina South Bend, Ind. | CBS |
| Wed Jan 8, 7:00 ET | at NC State Raleigh, NC | ESPN2/U |
| Sat Jan 11, 12:00 ET | at Duke Durham, NC | ESPN |
| Mon Jan 13, 7:00 ET | vs Boston College South Bend, Ind. | ACCN |
| Sat Jan 18, 4:00 ET | at Syracuse Syracuse, N.Y. | ACCN |
| Sat Jan 18, 4:00 ET | at Syracuse Syracuse, N.Y. | ACCN |
| Sat Jan 25, 6:30 ET | at Virginia Charlottesville, VA | ESPN/2 |
| Tue Jan 28, 9:00 ET | vs Georgia Tech South Bend, Ind. | ACCN |
| Sat Feb 1, 8:00 ET | at Miami Coral Gables, FL | ESPN2 |
| Tue Feb 4, 7:00 ET | at Florida State Tallahassee, Fla. | ACCN |
| Sat Feb 8, 1:00 ET | vs Virginia Tech South Bend, Ind. | The CW |
| Wed Feb 12, 9:00 ET | at Boston College Chestnut Hill, Mass. | ESPN2/U |
| Sun Feb 16, 8:00 ET | vs Louisville South Bend, Ind. | ACCN |
| Wed Feb 19, 7:00 ET | vs SMU South Bend, Ind. | ACCN |
| Sat Feb 22, 2:15 ET | vs Pitt South Bend, IN | The CW |
| Wed Feb 26, 7:00 ET | at Clemson Clemson, SC | ACCN |
| Sat Mar 1, 5:30 ET | at Wake Forest Winston-Salem, NC | The CW |
| Wed Mar 5, 9:00 ET | vs Stanford South Bend, Ind. | ESPN2/U |
| Sat Mar 8, 8:00 ET | vs California South Bend, IN | ESPNU |