| Date | Game | |
| Mon Nov 4, 5:00 ET | vs Mercyhurst South Bend, Ind. | W 105-61 |
| Sun Nov 10, 7:00 ET | at Purdue West Lafayette, Ind. | W 102-58 |
| Wed Nov 13, 7:00 ET | vs James Madison South Bend, Ind. | W 92-46 |
| Sun Nov 17, 2:00 ET | at Lafeyette Easton, PA | W 91-55 |
| Sat Nov 23, 4:00 ET | at USC | NBC |
| Fri Nov 29, 5:00 ET | vs TCU George Town, Cayman Islands | |
| Sat Nov 30, 5:00 ET | vs Utah George Town, Cayman Islands | |
| Thu Dec 5, 7:00 ET | vs Texas | ESPN |
| Sun Dec 8, 12:00 ET | at Syracuse | ACCN |
| Thu Dec 12, 7:00 ET | vs UConn | ACCNX |
| Sun Dec 15, 2:00 ET | vs Eastern Michigan | ACCNX |
| Sun Dec 22, 2:00 ET | vs Loyola Maryland South Bend, Ind. | |
| Sun Dec 29, 12:00 ET | vs Virginia South Bend, Ind. | |
| Sun Jan 5, 1:00 ET | at North Carolina Chapel Hill, NC | |
| Thu Jan 9, 7:00 ET | vs Wake Forest South Bend, Ind. | |
| Sun Jan 12, 12:00 ET | at Clemson Clemson, SC | |
| Thu Jan 16, 6:00 ET | vs Georgia Tech South Bend, Ind. | |
| Sun Jan 19, 6:00 ET | vs SMU South Bend, Ind. | |
| Thu Jan 23, 7:00 ET | at Boston College Chestnut Hill, Mass. | |
| Thu Jan 30, 6:00 ET | at Virginia Tech Blacksburg, VA | |
| Sun Feb 2, 12:00 ET | at Louisville Louisville, Ky. | |
| Thu Feb 6, 8:30 ET | vs Stanford South Bend, Ind. | |
| Sun Feb 9, 2:00 ET | vs California South Bend, Ind. | |
| Thu Feb 13, 8:00 ET | at Pitt Pittsburgh, PA | |
| Mon Feb 17, 6:00 ET | vs Duke South Bend, Ind. | |
| Thu Feb 20, 7:00 ET | at Miami Coral Gables, FL | |
| Sun Feb 23, 12:00 ET | at NC State Raleigh, N.C. | |
| Thu Feb 27, 8:00 ET | vs Florida State South Bend, Ind. | |
| Sun Mar 2 | vs Louisville South Bend, Ind. | |