| Date | Game | |
| Thu Aug 15, 7:00 ET | vs Michigan State South Bend, Ind. | L 1-2 |
| Sun Aug 18, 6:00 ET | at Samford Birmingham, AL | W 6-0 |
| Sun Aug 25, 1:00 ET | vs TCU South Bend, Ind. | W 4-0 |
| Thu Aug 29, 7:00 ET | at Michigan Ann Arbor, MI | W 2-0 |
| Sun Sep 1, 7:00 ET | at Butler Indianapolis, IN | W 1-0 |
| Thu Sep 5, 7:00 ET | vs Northern Illinois South Bend, Ind. | W 4-0 |
| Sun Sep 8, 1:30 ET | vs Marquette South Bend, Ind. | W 5-0 |
| Thu Sep 12, 7:00 ET | at Boston College Newton, Mass. | T 2-2 |
| Sun Sep 22, 12:00 ET | at Virginia Charlottesville, VA | W 1-0 |
| Thu Sep 26, 7:00 ET | vs NC State South Bend, Ind. | T 1-1 |
| Sat Oct 5, 1:00 ET | at Syracuse Syracuse, NY | W 3-0 |
| Sat Oct 12, 5:00 ET | at Louisville Louisville, Ky. | T 0-0 |
| Thu Oct 17, 7:00 ET | vs California South Bend, Ind. | W 5-2 |
| Sun Oct 20, 2:00 ET | vs Stanford South Bend, Ind. | W 3-0 |
| Thu Oct 24, 7:00 ET | at Duke Durham, N.C. | T 3-3 |
| Sun Oct 27, 1:00 ET | vs Virginia Tech South Bend, Ind. | L 0-2 |
| Thu Oct 31, 7:00 ET | vs Pitt South Bend, Ind. | W 3-2 |
| Sun Nov 3, 8:00 ET | at Florida State Tallahassee, FL | L 1-2 |
| Fri Nov 15, 7:00 ET | vs Milwaukee South Bend, Ind. | W 5-1 |
| Fri Nov 22, 3:30 ET | vs Kentucky | ESPN+ |