| Date | Game | |
| Mon Nov 4, 7:00 ET | vs Radford Pittsburgh, PA | W 96-56 |
| Fri Nov 8, 7:00 ET | vs Murray State Pittsburgh, PA | W 83-68 |
| Mon Nov 11, 7:00 ET | vs Gardner-Webb Pittsburgh, PA | W 83-64 |
| Fri Nov 15, 8:00 ET | vs West Virginia Pittsburgh, PA | W 86-62 |
| Mon Nov 18, 7:00 ET | vs VMI Pittsburgh, PA | W 93-48 |
| Fri Nov 22, 2:30 ET | vs LSU White Sulphur Springs, WV | W 74-63 |
| Sun Nov 24, 5:30 ET | vs Wisconsin | CBS Sports Network |
| Fri Nov 29, 2:30 ET | at Ohio State Columbus, OH | Peacock |
| Wed Dec 4, 9:15 ET | at Mississippi State | SECN |
| Sat Dec 7, 2:00 ET | at Virginia Tech | ESPNU |
| Wed Dec 11, 7:00 ET | vs Eastern Kentucky | ESPN+ |
| Sat Dec 21, 1:00 ET | vs Sam Houston Pittsburgh, PA | ACCNX |
| Wed Jan 1 | vs Cal Pittsburgh, PA | ACCN |
| Sat Jan 4, 6:30 ET | vs Stanford Pittsburgh, PA | ESPN2 |
| Tue Jan 7, 7:00 ET | at Duke Durham, NC | ESPN |
| Sat Jan 11, 12:00 ET | vs Louisville Pittsburgh, Pa. | ESPN2 |
| Wed Jan 15, 9:00 ET | at Florida State Tallahassee, FL | ESPNU |
| Sat Jan 18, 12:00 ET | vs Clemson Pittsburgh, PA | The CW |
| Sat Jan 25, 12:30 ET | at Syracuse Syracuse, N.Y. | ESPN2 |
| Sat Jan 25, 12:30 ET | at Syracuse Syracuse, N.Y. | ESPN2 |
| Tue Jan 28, 9:00 ET | vs North Carolina Pittsburgh, PA | ESPN |
| Sat Feb 1, 12:00 ET | at Wake Forest Winston-Salem, NC | ESPN/ESPN2 |
| Mon Feb 3, 7:00 ET | vs Virginia Pittsburgh, PA | ESPN |
| Sat Feb 8, 4:00 ET | at North Carolina Chapel Hill, NC | ESPN/ESPN2 |
| Tue Feb 11, 9:00 ET | at SMU Dallas, Texas | ACCN |
| Sat Feb 15, 12:00 ET | vs Miami Pittsburgh, PA | ESPN/ESPN2 |
| Tue Feb 18, 7:00 ET | vs Syracuse Pittsburgh, PA | ACCN |
| Tue Feb 18, 7:00 ET | vs Syracuse Pittsburgh, PA | ACCN |
| Sat Feb 22, 2:15 ET | at Notre Dame South Bend, IN | The CW |
| Tue Feb 25, 7:00 ET | vs Georgia Tech Pittsburgh, PA | ACCN |
| Sat Mar 1, 6:00 ET | at Louisville Louisville, Ky. | ESPN2 |
| Wed Mar 5, 7:00 ET | at NC State Raleigh, NC | ACCN |
| Sat Mar 8, 6:00 ET | vs Boston College Pittsburgh, PA | ACCN |