| Date | Game | |
| Tue Nov 9, 7:00 ET | vs The Citadel Petersen Events Center, Pittsburgh, PA | L 63-78 |
| Fri Nov 12, 8:30 ET | at West Virginia WVU Coliseum, Morgantown, WV | L 59-74 |
| Tue Nov 16, 7:00 ET | vs UNC Wilmington Petersen Events Center, Pittsburgh, PA | W 59-51 |
| Fri Nov 19, 6:00 ET | vs Towson Petersen Events Center, Pittsburgh, PA | W 63-59 |
| Wed Nov 24, 9:00 ET | vs Vanderbilt Petersen Events Center, Pittsburgh, PA | L 52-68 |
| Sat Nov 27, 2:00 ET | vs UMBC Petersen Events Center, Pittsburgh, PA | L 77-87 |
| Tue Nov 30, 7:00 ET | vs Minnesota Petersen Events Center, Pittsburgh, PA | L 53-54 |
| Fri Dec 3, 8:00 ET | at Virginia John Paul Jones Arena, Charlottesville, VA | L 56-57 |
| Thu Dec 9, 8:00 ET | vs Colgate Petersen Events Center, Pittsburgh, PA | W 71-68 |
| Sun Dec 12, 7:00 ET | vs Monmouth Petersen Events Center, Pittsburgh, PA | L 52-56 |
| Sat Dec 18, 12:00 ET | at St. John's Madison Square Garden, New York, NY | W 59-57 |
| Tue Dec 21, 2:00 ET | vs Jacksonville Petersen Events Center, Pittsburgh, PA | W 64-55 |
| Tue Dec 28, 8:00 ET | vs Notre Dame Petersen Events Center, Pittsburgh, PA | L 67-68 |
| Sat Jan 1, 4:00 ET | at Virginia Tech Cassell Coliseum, Blacksburg, VA | ESPNU |
| Sat Jan 1, 4:00 ET | vs Virginia Tech Petersen Events Center, Pittsburgh, PA | ACCN |
| Sat Jan 1, 4:00 ET | vs Virginia Tech Petersen Events Center, Pittsburgh, PA | ACCN |
| Wed Jan 5, 7:00 ET | at Louisville KFC Yum Center, Louisville, KY | L 72-75 |
| Sat Jan 8, 4:00 ET | vs Boston College Petersen Events Center, Pittsburgh, PA | ACCN |
| Sat Jan 8, 4:00 ET | vs Boston College Petersen Events Center, Pittsburgh, PA | W 69-67 |
| Sat Jan 8, 4:00 ET | at Boston College Conte Forum, Chestnut Hill, MA | ACCN |
| Tue Jan 11, 7:00 ET | at Syracuse Carrier Dome, Syracuse, NY | L 61-77 |
| Sat Jan 15, 4:00 ET | vs Louisville Petersen Events Center, Pittsburgh, PA | W 65-53 |
| Wed Jan 19, 9:00 ET | vs Virginia Petersen Events Center, Pittsburgh, PA | L 61-66 |
| Sat Jan 22, 6:00 ET | at Clemson Littlejohn Coliseum, Clemson, SC | L 48-75 |
| Tue Jan 25, 8:00 ET | vs Syracuse Petersen Events Center, Pittsburgh, PA | W 64-53 |
| Sun Jan 30, 4:00 ET | at Boston College Conte Forum, Chestnut Hill, MA | L 56-69 |
| Wed Feb 2, 7:00 ET | at Wake Forest LJVM Coliseum, Winston-Salem, NC | L 75-91 |
| Sat Feb 5, 7:00 ET | vs Virginia Tech Petersen Events Center, Pittsburgh, PA | L 71-76 |
| Mon Feb 7, 7:00 ET | at Virginia Tech Cassell Coliseum, Blacksburg, VA | L 47-74 |
| Wed Feb 9, 9:00 ET | at Florida State Donald L. Tucker Civic Center, Tallahassee, FL | W 56-51 |
| Sat Feb 12, 3:00 ET | vs NC State Petersen Events Center, Pittsburgh, PA | W 71-69 |
| Wed Feb 16, 8:00 ET | at North Carolina Smith Center, Chapel Hill, NC | W 76-67 |
| Sat Feb 19, 7:00 ET | vs Georgia Tech Petersen Events Center, Pittsburgh, PA | L 62-68 |
| Tue Feb 22, 8:00 ET | vs Miami Petersen Events Center, Pittsburgh, PA | L 64-85 |
| Tue Mar 1, 8:00 ET | vs Duke Petersen Events Center, Pittsburgh, PA | L 56-86 |
| Sat Mar 5, 2:30 ET | at Notre Dame Purcell Pavilion, Notre Dame, IN | L 54-78 |
| Tue Mar 8, 2:00 ET | vs Boston College Barclays Center, Brooklyn, NY | L 46-66 |