| Date | Game | |
| Fri Sep 4 | at Boston College Chestnut Hill, Mass. | |
| Sat Sep 12 | at Rutgers Piscataway, N.J. | |
Sat Sep 12
12:00 ET | at North Carolina Chapel Hill, N.C. | L 6-31 |
| Sat Sep 19 | vs Colgate Syracuse, N.Y. | |
Sat Sep 19
12:00 ET | at Pitt Pittsburgh, Pa. | L 10-21 |
| Sat Sep 26 | at Western Michigan Kalamazoo, Mich. | |
Sat Sep 26
12:00 ET | vs Georgia Tech Syracuse, N.Y. | W 37-20 |
| Sat Oct 3 | vs Louisville Syracuse, N.Y. | |
Sat Oct 10
12:30 ET | vs Duke Syracuse, N.Y. | L 24-38 |
| Sat Oct 17 | vs Liberty Syracuse, N.Y. | |
Sat Oct 17
12:00 ET | vs Liberty Syracuse, N.Y. | L 21-38 |
| Sat Oct 24 | at Clemson Clemson, S.C. | |
Sat Oct 24
12:00 ET | at Clemson Clemson, S.C. | L 21-47 |
| Sat Oct 31 | vs Georgia Tech Syracuse, N.Y. | |
Sat Oct 31
12:00 ET | vs Wake Forest Syracuse, N.Y. | L 14-38 |
| Sat Nov 7 | at Wake Forest Winston-Salem, N.C. | |
Sat Nov 7
2:00 ET | vs Boston College Syracuse, N.Y. | L 13-16 |
| Sat Nov 14 | vs NC State Syracuse, N.Y. | |
| Thu Nov 19 | vs Florida State Syracuse, N.Y. | |
Fri Nov 20
7:00 ET | at Louisville Louisville, Ky. | L 0-30 |
| Sat Nov 28 | at Pitt Pittsburgh, Pa. | |
Sat Nov 28
12:00 ET | vs NC State Syracuse, N.Y. | L 29-36 |
Sat Dec 5
2:30 ET | at Notre Dame Notre Dame, Ind. | L 21-45 |