| Date | Game | |
| Fri Feb 19, 4:00 ET | vs Kent State | ACCNX |
| Sun Feb 21, 11:00 AM ET | vs Kent State Blacksburg, Va. | W 3-1 |
| Sun Feb 21, 2:30 ET | vs Kent State Blacksburg, Va. | W 9-2 |
| Tue Feb 23, 2:00 ET | vs Radford Blacksburg, Va. | W 22-2 |
| Fri Feb 26, 7:00 ET | at Miami Coral Gables, Fla. | W 5-3 |
| Sat Feb 27, 7:00 ET | at Miami Coral Gables, Fla. | L 0-3 |
| Sun Feb 28, 1:00 ET | at Miami Coral Gables, Fla. | W 9-6 |
| Fri Mar 5, 4:00 ET | vs North Carolina Blacksburg, Va. | W 10-6 |
| Sat Mar 6, 3:00 ET | vs North Carolina Blacksburg, Va. | W 6-4 |
| Sun Mar 7, 1:00 ET | vs North Carolina Blacksburg, Va. | L 6-9 |
| Tue Mar 9, 4:00 ET | vs VCU Blacksburg, Va. | W 10-9 |
| Wed Mar 10, 3:00 ET | vs VCU Blacksburg, Va. | L 7-10 |
| Fri Mar 12, 4:00 ET | vs Florida State Blacksburg, Va. | L 4-6 |
| Sat Mar 13, 3:00 ET | vs Florida State Blacksburg, Va. | W 5-0 |
| Sun Mar 14, 1:00 ET | vs Florida State Blacksburg, Va. | L 7-14 |
| Tue Mar 16, 4:00 ET | vs UNC Greensboro Blacksburg, Va. | L 2-7 |
| Fri Mar 19, 6:00 ET | at Clemson Clemson, S.C. | L 2-8 |
| Sat Mar 20, 3:00 ET | at Clemson Clemson, S.C. | W 11-3 |
| Sun Mar 21, 1:00 ET | at Clemson Clemson, S.C. | L 2-4 |
| Fri Mar 26, 3:00 ET | at Pitt Pittsburgh, Pa. | W 5-1 |
| Sat Mar 27, 3:00 ET | at Pitt Pittsburgh, Pa. | W 8-4 |
| Sun Mar 28, 1:00 ET | at Pitt Pittsburgh, Pa. | W 8-4 |
| Thu Apr 1, 1:00 ET | vs Boston College Blacksburg, Va. | L 3-7 |
| Fri Apr 2, 3:00 ET | vs Boston College Blacksburg, Va. | W 6-5 |
| Sat Apr 3, 1:00 ET | vs Boston College Blacksburg, Va. | W 4-3 |
| Tue Apr 6, 5:00 ET | at East Tennessee State Johnson City, Tenn. | W 15-5 |
| Fri Apr 9, 6:00 ET | at Wake Forest Winston-Salem, N.C. | W 8-4 |
| Sat Apr 10, 1:00 ET | at Wake Forest Winston-Salem, N.C. | W 16-4 |
| Sun Apr 11, 1:00 ET | at Wake Forest Winston-Salem, N.C. | W 10-9 |
| Tue Apr 13, 6:00 ET | at Liberty Lynchburg, Va. | L 2-8 |
| Fri Apr 16, 6:00 ET | vs Georgia Tech Blacksburg, Va. | L 11-15 |
| Sat Apr 17, 3:00 ET | vs Georgia Tech Blacksburg, Va. | W 7-0 |
| Sun Apr 18, 1:00 ET | vs Georgia Tech Blacksburg, Va. | L 4-11 |
| Tue Apr 20, 6:00 ET | vs VMI Blacksburg, Va. | W 7-5 |
| Fri Apr 23, 6:30 ET | at NC State Raleigh, N.C. | L 1-3 |
| Sun Apr 25, 12:00 ET | at NC State Raleigh, N.C. | L 3-11 |
| Sun Apr 25, 4:00 ET | at NC State Raleigh, N.C. | L 6-7 |
| Tue Apr 27, 6:00 ET | vs East Tennessee State Blacksburg, Va. | W 12-0 |
| Fri Apr 30, 7:00 ET | vs Virginia Blacksburg, Va. | L 1-18 |
| Sat May 1, 7:00 ET | vs Virginia Blacksburg, Va. | W 6-3 |
| Sun May 2, 6:00 ET | vs Virginia Blacksburg, Va. | L 1-6 |
| Wed May 5, 6:00 ET | vs Georgetown Blacksburg, Va. | W 6-2 |
| Sat May 8, 2:00 ET | vs Toledo Blacksburg, Va. | W 7-1 |
| Sat May 8, 5:50 ET | vs Toledo Blacksburg, Va. | W 3-2 |
| Sun May 9, 2:00 ET | vs Toledo Blacksburg, Va. | W 16-5 |
| Fri May 14, 6:00 ET | at Duke Durham, N.C. | L 6-11 |
| Sat May 15, 1:00 ET | at Duke Durham, N.C. | L 1-4 |
| Sun May 16, 1:00 ET | at Duke Durham, N.C. | L 1-2 |
| Thu May 20, 6:00 ET | vs Notre Dame Blacksburg, Va. | L 2-8 |
| Fri May 21, 6:00 ET | vs Notre Dame Blacksburg, Va. | L 0-4 |
| Sat May 22, 1:00 ET | vs Notre Dame Blacksburg, Va. | L 1-7 |
| Tue May 25 | vs 2021 ACC Baseball Tournament TBD | |
| Tue May 25, 3:00 ET | vs Virginia Charlotte, NC | L 2-3 |
| Wed May 26, 3:00 ET | vs Notre Dame Charlotte, NC | L 0-8 |