| Date | Game | |
| Sat Sep 5 | vs Liberty Blacksburg, Va. | |
| Sat Sep 12 | vs Penn State Blacksburg, Va. | |
| Sat Sep 19 | at Middle Tennessee State Murfreesboro, Tenn. | |
| Sat Sep 26 | vs North Alabama Blacksburg, Va. | |
| Sat Sep 26, 8:00 ET | vs NC State Blacksburg, Va. | W 45-24 |
| Sat Oct 3 | vs Georgia Tech Blacksburg, Va. | |
| Sat Oct 3, 4:00 ET | at Duke Durham, N.C. | W 38-31 |
| Sat Oct 10 | at North Carolina Chapel Hill, N.C. | |
| Sat Oct 10, 12:00 ET | at North Carolina Chapel Hill, N.C. | L 45-56 |
| Sat Oct 17, 8:00 ET | vs Boston College Blacksburg, Va. | W 40-14 |
| Thu Oct 22 | vs Boston College Blacksburg, Va. | |
| Sat Oct 24, 3:30 ET | at Wake Forest Winston-Salem, N.C. | L 16-23 |
| Sat Oct 31 | at Louisville Louisville, Ky. | W 42-35 |
| Sat Oct 31 | at Louisville Louisville, Ky. | |
| Fri Nov 6 | at Pitt Pittsburgh, Pa. | |
| Sat Nov 7, 12:00 ET | vs Liberty Blacksburg, Va. | L 35-38 |
| Sat Nov 14 | vs Miami Blacksburg, Va. | |
| Sat Nov 14, 12:00 ET | vs Miami Blacksburg, Va. | L 24-25 |
| Sat Nov 21, 12:00 ET | at Duke Durham, N.C. | |
| Sat Nov 21, 4:00 ET | at Pitt Pittsburgh, Pa. | L 14-47 |
| Sat Nov 28 | vs Virginia Blacksburg, Va. | |
| Sat Dec 5, 7:30 ET | vs Clemson Blacksburg, Va. | L 10-45 |
| Sat Dec 12, 8:00 ET | vs Virginia Blacksburg, Va. | W 33-15 |