| Date | Game | |
| Mon Nov 4, 8:00 ET | vs Delaware State Blacksburg, VA | ACCNX |
| Fri Nov 8, 7:00 ET | vs USC Upstate Blacksburg, VA | ACCNX |
| Mon Nov 11, 7:00 ET | vs Winthrop Blacksburg, VA | ACCNX |
| Fri Nov 15, 7:30 ET | vs Penn State Baltimore, MD | Peacock |
| Wed Nov 20, 7:00 ET | vs Jacksonville Blacksburg, Va. | ACCNX |
| Mon Nov 25, 6:00 ET | vs Michigan Fort Myers, FL | FS1 |
| Wed Nov 27, 6:00 ET | vs South Carolina/Xavier Fort Myers, Fla. | FS1 |
| Wed Dec 4, 9:15 ET | vs Vanderbilt Blacksburg, VA | ACCN |
| Sat Dec 7, 2:00 ET | vs Pitt Blacksburg, VA | ESPNU |
| Thu Dec 12, 7:00 ET | vs North Carolina A&T Blacksburg, VA | ACCNX |
| Sun Dec 15, 12:00 ET | vs Navy Blacksburg, VA | ACCNX |
| Sat Dec 21, 12:00 ET | vs Saint Joseph's Philadelphia, PA | CBSSN |
| Tue Dec 31, 4:30 ET | at Duke Durham, NC | ACCN |
| Sat Jan 4, 2:00 ET | vs Miami Blacksburg, VA | ACCN |
| Wed Jan 8, 6:00 ET | at Stanford Stanford, CA | ACCN |
| Sat Jan 11, 6:00 ET | at California Berkeley, CA | ACCN |
| Wed Jan 15, 7:00 ET | vs NC State Blacksburg, VA | ESPNU |
| Sat Jan 18, 2:00 ET | vs Wake Forest Blacksburg, VA | ACCN |
| Wed Jan 22, 7:00 ET | at Georgia Tech Atlanta, GA | ESPN2/U |
| Sat Jan 25, 5:00 ET | vs Clemson Blacksburg, VA | ACCN |
| Wed Jan 29, 7:00 ET | at Florida State Tallahassee, Fla. | ACCN |
| Sat Feb 1, 4:00 ET | at Virginia Charlottesville, VA | ACCN |
| Wed Feb 5, 9:00 ET | vs SMU Blacksburg, VA | ACCN |
| Sat Feb 8, 1:00 ET | at Notre Dame South Bend, Ind. | The CW |
| Sat Feb 15, 5:30 ET | vs Virginia Blacksburg, VA | The CW |
| Tue Feb 18, 9:00 ET | at Boston College Chestnut Hill, Mass. | ACCN |
| Sat Feb 22, 6:00 ET | at Miami Coral Gables, FL | ACCN |
| Tue Feb 25, 9:00 ET | vs Louisville Blacksburg, Va. | ACCN |
| Sat Mar 1, 12:00 ET | vs Syracuse Blacksburg, VA | The CW |
| Tue Mar 4, 7:00 ET | vs North Carolina Blacksburg, Va. | ESPN, ESPN2 or ESPNU |
| Sat Mar 8, 6:00 ET | at Clemson Clemson, SC | ESPNU |